François Lab

Publications

2026

Decoding the Central Dogma: Quantitative Insights into Transcription and Translation Dynamics in the p53-Mediated DNA Damage Response
Joshua François, Ashwini Jambhekar, Galit Lahav
Journal of Molecular Biology  ·  01 Jan 2026  ·  doi:10.1016/j.jmb.2025.169436

2024

Temporal regulation of gene expression through integration of p53 dynamics and modifications
Dan Lu, Marjan Faizi, Bryon Drown, Alina Simerzin, Joshua François, Gary Bradshaw, Neil Kelleher, Ashwini Jambhekar, Jeremy Gunawardena, Galit Lahav
Science Advances  ·  25 Oct 2024  ·  doi:10.1126/sciadv.adp2229

2021

The interplay between matrix deformation and the coordination of turning events governs directed neutrophil migration in 3D matrices
Joshua François, Adithan Kandasamy, Yi-Ting Yeh, Amy Schwartz, Cindy Ayala, Ruedi Meili, Shu Chien, Juan C. Lasheras, Juan C. del Álamo
Science Advances  ·  16 Jul 2021  ·  doi:10.1126/sciadv.abf3882

2017

Three-dimensional forces exerted by leukocytes and vascular endothelial cells dynamically facilitate diapedesis
Yi-Ting Yeh, Ricardo Serrano, Joshua François, Jeng-Jiann Chiu, Yi-Shuan Julie Li, Juan C. del Álamo, Shu Chien, Juan C. Lasheras
Proceedings of the National Academy of Sciences  ·  18 Dec 2017  ·  doi:10.1073/pnas.1717489115

2015

Numerical model for the deformation of nucleated cells by optical stretchers
Ihab Sraj, Joshua Francois, David W M Marr, Charles D Eggleton
Journal of Optics  ·  01 Jul 2015  ·  doi:10.1088/2040-8978/17/7/075403

2014

Both contractile axial and lateral traction force dynamics drive amoeboid cell motility
Effie Bastounis, Ruedi Meili, Begoña Álvarez-González, Joshua Francois, Juan C. del Álamo, Richard A. Firtel, Juan C. Lasheras
Journal of Cell Biology  ·  17 Mar 2014  ·  doi:10.1083/jcb.201307106